Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 14/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.69 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.69 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.69 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.69 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934477 | 0.88 | SLC6A4 (0.52) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6937417 | 0.86 | SLC6A4 (0.67) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6936956 | 0.85 | SLC6A2 (0.49) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6937450 | 0.85 | SLC6A2 (0.49) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6936991 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6939036 | 0.84 | SLC6A4 (0.48) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL6939500 | 0.83 | SLC6A2 (0.47) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| SCHEMBL4667320 | 0.83 | OPRK1 (0.50) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| Hydrochloric Acid SCHEMBL7739135 | 0.82 | SLC6A2 (0.47) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 | |
| (R,R)-Tramadol SCHEMBL57495 | 0.82 | SLC6A2 (1.00) | SLC6A4SLC6A2OPRM1SLC22A1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | claimed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | claimed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | claimed |
| EP-1043307-B1 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | GRUENENTHAL GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6410790-B1 | ANALGESICS | GRUENENTHAL GMBH (DE) | 2002-06-25 | — | — | US | disclosed |
| JP-2000327642-A | 3-AMINO-3-ARYLPROPAN-1-OL DERIVATIVE, ITS PRODUCTION AND USE | GRUENENTHAL GMBH | 2000-11-28 | — | — | JP | disclosed |
| EP-1043307-A2 | 3-amino-3-arylpropan-1-ol-derivates, their preparation and their use | Grünenthal GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |