Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236121 | 0.83 | PDE5A (0.41) | KDM4EALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL3222570 | 0.81 | USP2 (0.44) | KDM4EALDH1A1HSD17B10PDE5AMEN1 | |
| SCHEMBL29564141 | 0.73 | GDA (0.49) | ALDH1A1GDAPNP | |
| SCHEMBL1970070 | 0.73 | GDA (0.58) | ALDH1A1GAAGDASMN1; SMN2MAPT | |
| SCHEMBL5798037 | 0.72 | GRIA1 (0.45) | PDE5AGDASLC2A1PNP | |
| SCHEMBL29131184 | 0.71 | PNP (0.43) | ALDH1A1PDE5AGDASLC2A1PNP | |
| SCHEMBL18343349 | 0.70 | SMN1; SMN2 (0.51) | KDM4EALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL1286929 | 0.69 | PNP (0.50) | ALDH1A1PDE5AGDASLC2A1PNP | |
| SCHEMBL8591405 | 0.69 | GDA (0.52) | ALDH1A1GDAPNP | |
| SCHEMBL3433603 | 0.69 | TSHR (0.52) | TSHRGAANPSR1PDE5AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573045-B1 | Reporter molecule and RNA target molecule, both carrying a fluorescent or chromogenic group, placed in close proximity to each other; addition of test compound inhibits their binding and increases fluorescence; drug screening | RIBOTARGETS, LTD. (GB) | 2003-06-03 | — | — | US | disclosed |
| EP-1144681-A3 | METHODS AND KITS FOR DISCOVERY OF RNA-BINDING COMPOUNDS | RiboTargets Limited (GB) | 2001-11-28 | — | — | EP | disclosed |
| EP-1144681-A2 | METHODS AND KITS FOR DISCOVERY OF RNA-BINDING COMPOUNDS | RiboTargets Limited (GB) | 2001-10-17 | — | — | EP | disclosed |
| WO-1999064625-A2 | METHODS AND KITS FOR DISCOVERY OF RNA-BINDING COMPOUNDS | RIBOTARGETS LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |