SCHEMBL1970070

SCHEMBL1970070

O=C(COc1ccccc1)Nc1nc2nc[nH]c2c(=O)[nH]1

nearest known ligand 0.60

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.58
NPC1 O15118 2/20 0.57
RAB9A P51151 2/20 0.57
ALDH1A1 P00352 1/20 0.57
TP53 P04637 1/20 0.57
ALOX12 P18054 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
ALPL P05186 1/20 0.51
MAPT P10636 1/20 0.47
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5198603 0.83 GDA (0.61) GDAALDH1A1
SCHEMBL3072990 0.83 GDA (0.67) GDA
SCHEMBL1970068 0.82 NPC1 (0.58) NPC1RAB9AALDH1A1TP53ALOX12
SCHEMBL25398222 0.81 GDA (0.58) GDAALPL
SCHEMBL1425019 0.79 GDA (0.65) GDANPC1RAB9ASMN1; SMN2
SCHEMBL29411658 0.78 GDA (0.76) GDA
SCHEMBL8583453 0.78 GDA (0.57) GDA
SCHEMBL5694112 0.78 NPC1 (0.49) NPC1RAB9AALDH1A1TP53ALOX12
SCHEMBL5694094 0.77 XDH (0.51) NPC1RAB9AALDH1A1TP53ALOX12
SCHEMBL8843889 0.77 GDA (0.69) GDA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11987599-B2 Solid support for synthesizing nucleic acid sequences and methods for making and using UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-05-21 US claimed
US-20230271998-A1 SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-08-31 US claimed
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2019-05-14 US claimed
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-11-24 US claimed
EP-2334692-B1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS UNIV MCGILL (CA) 2016-04-13 EP claimed
US-9249175-B2 RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays THE ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2016-02-02 US claimed
US-20120178638-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-07-12 US claimed
EP-2334692-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS The Royal Institution for the Advancement of Learning / McGill University (CA) 2011-06-22 EP claimed
WO-2010025566-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2010-03-11 WO claimed
US-20260117282-A1 High Throughput Cell-Based Screening For Aptamers MEIRAGTX GENE REGULATION LTD (GB) 2026-04-30 US disclosed
US-11987599-B2 Solid support for synthesizing nucleic acid sequences and methods for making and using UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-05-21 US disclosed
CN-117721110-A Antisense nucleic acid 日本新药株式会社 2024-03-19 CN disclosed
CN-110199030-B Cell-based high throughput aptamer screening 梅里特斯英国第二有限公司 2023-12-12 CN disclosed
EP-3494229-B1 HIGH THROUGHPUT CELL-BASED SCREENING FOR APTAMERS MEIRAGTX UK II LTD (GB) 2023-10-25 EP disclosed
WO-2018025085-A2 HIGH THROUGHPUT CELL-BASED SCREENING FOR APTAMERS MEIRAGTX UK II LIMITED (GB) 2018-02-08 WO disclosed
US-9738681-B2 Intermediate for production of nucleoside analog and method for producing the same DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-22 US disclosed
US-20160068561-A9 Intermediate for Production of Nucleoside Analog and Method for Producing the Same DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-10 US disclosed
US-20150152132-A1 Intermediate for Production of Nucleoside Analog and Method for Producing the Same DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-06-04 US disclosed
EP-2862868-A1 INTERMEDIATE FOR PRODUCTION OF NUCLEOSIDE ANALOGUE, AND METHOD FOR PRODUCING SAME DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-04-22 EP disclosed
EP-1645561-A1 METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE Mitsui Chemicals, Inc. (JP) 2006-04-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10287313-B2 RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays EFTUD2, RNMT, NSUN2 GDA 539/4885NPC1 4871/4885RAB9A 4371/4885
US-20150152132-A1 Intermediate for Production of Nucleoside Analog and Method for Producing the Same RNGTT, NSUN2, RNMT GDA 119/4885NPC1 1755/4885RAB9A 3756/4885
US-20160068561-A9 Intermediate for Production of Nucleoside Analog and Method for Producing the Same RNGTT, NSUN2, RNMT GDA 119/4885NPC1 1755/4885RAB9A 3756/4885
US-20260117282-A1 High Throughput Cell-Based Screening For Aptamers CPSF6, TIA1, UPF1 GDA 1826/4885NPC1 2101/4885RAB9A 2699/4885
US-20160340382-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS EFTUD2, RNMT, RNGTT GDA 562/4885NPC1 4873/4885RAB9A 4368/4885
US-11987599-B2 Solid support for synthesizing nucleic acid sequences and methods for making and using RNGTT, NSUN2, POLN GDA 264/4885NPC1 1881/4885RAB9A 3828/4885
US-20120178638-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS EFTUD2, RNMT, RNGTT GDA 562/4885NPC1 4873/4885RAB9A 4368/4885
US-20230271998-A1 SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING RNGTT, NSUN2, POLN GDA 264/4885NPC1 1881/4885RAB9A 3828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.