Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015841 | 0.91 | DRD2 (0.53) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2017178 | 0.91 | DRD2 (0.53) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2015062 | 0.81 | DRD2 (0.53) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2013952 | 0.81 | DRD2 (0.53) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL1351177 | 0.77 | DRD2 (0.55) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL691879 | 0.75 | DRD2 (0.48) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2016632 | 0.75 | DRD2 (0.47) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2017655 | 0.75 | DRD2 (0.47) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL2019817 | 0.72 | DRD2 (0.44) | DRD2CHRM3CHRM2DRD4DRD3 | |
| SCHEMBL691313 | 0.72 | DRD2 (0.47) | DRD2CHRM3CHRM2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |