Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 9/20 | 0.55 |
| ▸ | PPARG | P37231 | 8/20 | 0.55 |
| ▸ | PPARA | Q07869 | 8/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6933376 | 0.84 | PPARG (0.57) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL7042280 | 0.81 | PPARG (0.65) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6937867 | 0.81 | PPARG (0.54) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936613 | 0.80 | PPARG (0.70) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6937386 | 0.79 | PPARG (0.84) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6933762 | 0.78 | PPARG (0.69) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6934160 | 0.78 | PPARG (0.74) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6935493 | 0.78 | PPARG (0.85) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6936719 | 0.78 | PPARG (0.85) | PPARDPPARGPPARANR1H2NR1H3 | |
| SCHEMBL6935505 | 0.78 | PPARG (0.73) | PPARDPPARGPPARANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888278-B1 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-0888278-A4 | ANTIDIABETIC AGENTS | MERCK & CO INC (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0888278-A1 | ANTIDIABETIC AGENTS | Merck & Co., Inc. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028115-A1 | ANTIDIABETIC AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |