Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733678 | 0.79 | NISCH (1.00) | NISCHADRA2AADRA2B | |
| SCHEMBL29196044 | 0.75 | HSD17B10 (0.46) | HSD17B10RIPK1PDPK1 | |
| SCHEMBL13731843 | 0.75 | NISCH (0.63) | NISCHADRA2AADRA2B | |
| SCHEMBL6937198 | 0.73 | ADRA2A (0.59) | NISCHADRA2AADRA2B | |
| SCHEMBL13733803 | 0.73 | NISCH (0.76) | NISCHADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL7869920 | 0.72 | ADRA2A (0.58) | NISCHADRA2AADRA2B | |
| SCHEMBL13731705 | 0.72 | NISCH (1.00) | NISCHADRA2AADRA2B | |
| SCHEMBL13731943 | 0.72 | NISCH (0.94) | NISCHADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL15467539 | 0.72 | NISCH (0.74) | NISCHADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL15467688 | 0.71 | NISCH (0.97) | NISCHADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1101756-B1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | claimed |
| US-6300366-B1 | FOR THERAPY OF CARDIOVASCULAR DISEASES, ESPECIALLY ARTERIAL HYPERTENSION, ARRHYTHMIA | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | claimed |
| EP-1101756-A1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | claimed |
| EP-1101756-B1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-6300366-B1 | FOR THERAPY OF CARDIOVASCULAR DISEASES, ESPECIALLY ARTERIAL HYPERTENSION, ARRHYTHMIA | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-1101756-A1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | disclosed |