Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 17/20 | 0.79 |
| ▸ | KCNQ1 | P51787 | 17/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484420 | 1.00 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6938497 | 1.00 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6938528 | 0.93 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL8486301 | 0.93 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6938527 | 0.93 | KCNE1 (0.79) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6935069 | 0.92 | KCNE1 (0.72) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL8482287 | 0.92 | KCNE1 (0.72) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6935071 | 0.92 | KCNE1 (0.72) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL8479397 | 0.91 | KCNE1 (0.77) | KCNE1KCNQ1KCNH2MEN1CYP1A2 | |
| SCHEMBL6931997 | 0.91 | KCNE1 (0.77) | KCNE1KCNQ1KCNH2MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0913396-B1 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6008245-A | TREATMENT OF PROPHYLAXIS AND CARDIOVASCULAR DISORDERS, IN PARTICULAR ARRHYTHMIAS, FOR THE TREATMENT OF ULCERS OF THE GASTROINTESTINAL DISORDERS, DIARRHEAL DISEASES | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 1999-12-28 | — | — | US | disclosed |
| EP-0913396-A2 | Sulphonamide substituted benzopyran derivatives, process of preparation, their use as medicines and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-06 | — | — | EP | disclosed |