Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.67 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936605 | 0.81 | P2RX7 (1.00) | P2RX7POLBNPSR1KMT2AMEN1 | |
| SCHEMBL6379951 | 0.78 | EPHX1 (0.50) | MAOBEPHX1NPC1MAPTRAB9A | |
| SCHEMBL29431165 | 0.76 | P2RX7 (0.83) | P2RX7GPR55CA12CA9POLB | |
| SCHEMBL6942663 | 0.76 | P2RX7 (0.83) | P2RX7GPR55CA12CA9POLB | |
| SCHEMBL2535295 | 0.76 | NOTUM (0.61) | MAOBEPHX1NOTUMNPC1MAPT | |
| SCHEMBL1948423 | 0.76 | MAOB (0.64) | MAOBEPHX1NOTUMNPC1MAPT | |
| SCHEMBL3321984 | 0.75 | P2RX7 (0.72) | P2RX7GPR55CA12CA9POLB | |
| SCHEMBL22775754 | 0.75 | P2RX7 (0.63) | P2RX7GPR55CA12CA9POLB | |
| SCHEMBL6385058 | 0.75 | EPHX1 (0.47) | MAOBEPHX1NOTUMNPC1MAPT | |
| SCHEMBL6937002 | 0.75 | P2RX7 (0.57) | P2RX7GPR55CA12CA9POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |