Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 4/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.54 |
| ▸ | PPARG | P37231 | 3/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865699 | 0.85 | PPARG (0.63) | MAOBPPARAPPARDFFAR1PPARG | |
| SCHEMBL6005310 | 0.85 | FPR2 (0.51) | PPARAPPARDPPARGCYP2C19 | |
| SCHEMBL6005718 | 0.85 | FPR2 (0.51) | PPARAPPARDPPARGCYP2C19 | |
| SCHEMBL6003758 | 0.85 | FPR2 (0.51) | PPARAPPARDPPARGCYP2C19 | |
| SCHEMBL8332027 | 0.81 | PPARG (0.64) | MAOBPPARAPPARDFFAR1PPARG | |
| SCHEMBL1152037 | 0.79 | FFAR1 (0.61) | MAOBMAOAFFAR1S1PR1HTR2A | |
| SCHEMBL4796227 | 0.78 | NPC1 (0.60) | MAOBMAOAFFAR1S1PR1HTR2A | |
| SCHEMBL366521 | 0.76 | NR4A2 (0.69) | S1PR1HTR2AKCNH2SIGMAR1S1PR5 | |
| SCHEMBL9109006 | 0.76 | CYP2C9 (0.49) | PPARAPPARGNPC1CYP2D6CYP2C19 | |
| SCHEMBL11854931 | 0.75 | MAOB (0.54) | MAOBMAOAFFAR1PPARGS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206463-A4 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1206463-A1 | FATTY ACID SYNTHASE INHIBITORS | SmithKline Beecham Corporation (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001014362-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-01 | — | — | WO | disclosed |