Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694379 | 0.90 | SMN1; SMN2 (0.45) | USP2CYP3A4SMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL12693489 | 0.89 | MAPK1 (0.45) | USP2CYP3A4ALDH1A1HIF1ATSHR | |
| SCHEMBL12317732 | 0.86 | CACNA1H (0.44) | CACNA1HUSP2CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL12253174 | 0.86 | KMT2A (0.51) | USP2SMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL693221 | 0.86 | USP2 (0.50) | USP2CYP3A4SMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL12693483 | 0.84 | CACNA1H (0.46) | CACNA1HUSP2CYP3A4SMN1; SMN2LMNA | |
| SCHEMBL12253135 | 0.82 | CACNA1H (0.42) | CACNA1HUSP2CYP3A4SMN1; SMN2ALDH1A1 | |
| SCHEMBL12693492 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL694272 | 0.81 | MEN1 (0.52) | CYP3A4SMN1; SMN2LMNACYP2C9TSHR | |
| SCHEMBL3109989 | 0.81 | TBXA2R (0.54) | CYP3A4ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502921-B1 | Arylsulfonamide CCR3 antagonists | AXIKIN PHARMACEUTICALS INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-8658642-B2 | Arylsulfonamide CCR3 antagonists | AXIKIN PHARMACEUTICALS, INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130217687-A1 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | AXIKIN PHARMACEUTICALS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-8420639-B2 | Arylsulfonamide CCR3 antagonists | AXIKIN PHARMACEUTICALS, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2502921-A1 | Arylsulfonamide CCR3 antagonists | Axikin Pharmaceuticals, Inc. (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2421838-A2 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | Axikin Pharmaceuticals, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20100273795-A1 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | AXIKIN PHARMACEUTICALS, INC. (US) | 2010-10-28 | — | — | US | disclosed |
| WO-2010123960-A2 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | AXIKIN PHARMACEUTICALS, INC. (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273795-A1 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | CCR3, CCR1, CCR4 | CACNA1H 3704/4885USP2 1309/4885CYP3A4 3259/4885 |
| US-20130217687-A1 | ARYLSULFONAMIDE CCR3 ANTAGONISTS | CCR3, CCR1, CCR4 | CACNA1H 3704/4885USP2 1309/4885CYP3A4 3259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.