Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 14/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945095 | 0.87 | NOS2 (0.59) | NOS2GAAMAPTALDH1A1 | |
| SCHEMBL6941212 | 0.84 | NOS2 (0.72) | NOS2MAPTTSHRMEN1KMT2A | |
| SCHEMBL6937888 | 0.84 | NOS2 (0.72) | NOS2MAPTTSHRMEN1KMT2A | |
| SCHEMBL6941446 | 0.84 | NOS2 (0.61) | NOS2GAALMNAMAPTTSHR | |
| SCHEMBL6947390 | 0.84 | NOS2 (0.61) | NOS2GAALMNAMAPTTSHR | |
| SCHEMBL6946779 | 0.81 | NOS2 (0.61) | NOS2MAOAMAOB | |
| SCHEMBL6946080 | 0.80 | NOS2 (0.59) | NOS2MAOAMAOB | |
| SCHEMBL6942481 | 0.80 | NOS2 (0.61) | NOS2MAOAMAOB | |
| SCHEMBL6940223 | 0.77 | NOS2 (0.75) | NOS2MAPTTSHRALDH1A1MEN1 | |
| SCHEMBL6942303 | 0.77 | NOS2 (0.75) | NOS2MAPTTSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268471-B1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | SCHERING AG (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-1268471-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072744-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-10-04 | — | — | WO | disclosed |