Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945973 | 0.83 | P2RX7 (0.63) | P2RX7KMT2AP2RX3LMNAMAPT | |
| SCHEMBL6941341 | 0.82 | P2RX7 (1.00) | P2RX7KMT2AP2RX3 | |
| SCHEMBL6860227 | 0.82 | P2RX7 (1.00) | P2RX7P2RX3LMNAMAPTMAPK1 | |
| SCHEMBL6941160 | 0.81 | P2RX7 (0.67) | P2RX7KMT2A | |
| SCHEMBL6939157 | 0.80 | P2RX7 (0.82) | P2RX7P2RX3LMNAMAPTMAPK1 | |
| SCHEMBL6941644 | 0.79 | P2RX7 (1.00) | P2RX7P2RX3LMNAMAPTMAPK1 | |
| SCHEMBL6939213 | 0.75 | P2RX7 (0.59) | P2RX7ALDH1A1 | |
| SCHEMBL6939826 | 0.74 | P2RX7 (0.68) | P2RX7ALDH1A1 | |
| SCHEMBL7570184 | 0.74 | P2RX7 (0.65) | P2RX7KMT2AMEN1ALDH1A1 | |
| SCHEMBL6943094 | 0.73 | P2RX7 (0.78) | P2RX7KMT2ALMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | claimed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | claimed |
| EP-1036058-B1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | EP | disclosed |
| US-6242470-B1 | RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS, ANTIALLERGENS; IRRITABLE BOWEL SYNDROME; AMIDATION | ASTRAZENECA AB (SE) | 2001-06-05 | — | — | US | disclosed |