Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425103 | 1.00 | CHRNB4 (0.50) | CHRNB4CHRNA3HTR2CIDO1PDPK1 | |
| SCHEMBL2913620 | 0.91 | CHRNB4 (0.44) | CHRNB4CHRNA3HTR2CIDO1PDPK1 | |
| SCHEMBL30166929 | 0.87 | CHRNB4 (0.59) | CHRNB4CHRNA3HTR2CIDO1PDPK1 | |
| SCHEMBL221689 | 0.87 | CHRNB4 (0.59) | CHRNB4CHRNA3HTR2CIDO1PDPK1 | |
| SCHEMBL779938 | 0.87 | CHRNB4 (0.46) | CHRNB4CHRNA3HTR2CHTR1A | |
| SCHEMBL23797352 | 0.87 | CHRNB4 (0.59) | CHRNB4CHRNA3HTR2CIDO1PDPK1 | |
| SCHEMBL29289209 | 0.86 | HTR2A (0.41) | CHRNB4CHRNA3HTR2CIDO1 | |
| SCHEMBL42781 | 0.84 | PTGDR2 (0.48) | CHRNB4CHRNA3HTR2C | |
| SCHEMBL31389967 | 0.82 | CHRNB4 (0.43) | CHRNB4CHRNA3HTR2C | |
| SCHEMBL3453584 | 0.80 | HTR2C (0.39) | CHRNB4CHRNA3HTR2CIDO1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114835644-A | Preparation method of sedaxane | 江苏百康德医药科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| EP-1101756-B1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-03-19 | — | — | EP | disclosed |
| US-6300366-B1 | FOR THERAPY OF CARDIOVASCULAR DISEASES, ESPECIALLY ARTERIAL HYPERTENSION, ARRHYTHMIA | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-1101756-A1 | Aminopyrrolidine derivatives, processes for their preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-05-23 | — | — | EP | disclosed |