Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 6/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | MMP10 | P09238 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946836 | 0.95 | ADAM17 (0.49) | ADAM17APPMMP1MMP2MMP9 | |
| SCHEMBL6943975 | 0.90 | ADAM17 (0.56) | ADAM17APPMMP1MMP2MMP9 | |
| SCHEMBL6942509 | 0.88 | ADAM17 (0.55) | ADAM17APPMMP1MMP2MMP9 | |
| SCHEMBL7100568 | 0.87 | ADAM17 (0.53) | ADAM17APPMMP1MMP2MMP9 | |
| SCHEMBL7100919 | 0.87 | ADAM17 (0.51) | ADAM17 | |
| SCHEMBL7104739 | 0.86 | ADAM17 (0.52) | ADAM17 | |
| SCHEMBL6946243 | 0.86 | ADAM17 (0.53) | ADAM17APPMMP2MMP9TGFBR1 | |
| SCHEMBL6945333 | 0.86 | ADAM17 (0.55) | ADAM17APPMMP1MMP2MMP9 | |
| SCHEMBL7105146 | 0.86 | ADAM17 (0.55) | ADAM17TGFBR1P2RX3 | |
| SCHEMBL6947186 | 0.85 | ADAM17 (0.52) | ADAM17APPMMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |