Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507774 | 1.00 | KMT2A (0.44) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL6944883 | 0.85 | KMT2A (0.47) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL22184593 | 0.79 | KMT2A (0.51) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL2622288 | 0.77 | GABBR2 (0.47) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL13812977 | 0.76 | GABBR2 (0.51) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL4711841 | 0.76 | GABBR2 (0.46) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL4713140 | 0.76 | GABBR2 (0.46) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL6940661 | 0.76 | MEN1 (0.46) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL6944320 | 0.75 | KMT2A (0.45) | KMT2AMEN1GABBR2CYP1A2CYP2C9 | |
| SCHEMBL4065318 | 0.75 | KMT2A (0.50) | KMT2AMEN1GABBR2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |