Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.54 |
| ▸ | MMP3 | P08254 | 12/20 | 0.44 |
| ▸ | MMP1 | P03956 | 10/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 11/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 8/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940783 | 1.00 | ADAM17 (0.54) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6940789 | 1.00 | ADAM17 (0.54) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL6940779 | 1.00 | ADAM17 (0.54) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL7836616 | 0.83 | ADAM17 (0.53) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL7955133 | 0.83 | ADAM17 (0.55) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL1844385 | 0.83 | ADAM17 (0.55) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL1844380 | 0.83 | ADAM17 (0.55) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL13274078 | 0.83 | ADAM17 (0.55) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL7955135 | 0.83 | ADAM17 (0.55) | ADAM17MMP3MMP1MMP9MMP14 | |
| SCHEMBL7940327 | 0.79 | ADAM17 (0.56) | ADAM17MMP3MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |