Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | CCKBR | P32239 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934431 | 0.92 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL6940247 | 0.87 | NPSR1 (0.68) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL12143205 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL8672792 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL8670183 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL4992176 | 0.84 | CYP1A2 (0.59) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL7945100 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL9089011 | 0.83 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL8546479 | 0.82 | KDM4E (0.46) | SMN1; SMN2KDM4ENPSR1GAAHTT | |
| SCHEMBL8548821 | 0.82 | CYP1A2 (0.48) | SMN1; SMN2KDM4ENPSR1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1342719-A1 | Benzodiazepine derivatives useful as CCK-Receptor Antagonists | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-09-10 | — | — | EP | disclosed |
| EP-0538945-A1 | Benzodiazepine derivatives, and their use as antagonists of gastrin and/or cholecystokinin | GLAXO GROUP LIMITED (GB) | 1993-04-28 | — | — | EP | disclosed |