Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8672792 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL12143205 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL12143204 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL9089011 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL14095674 | 0.85 | HDAC1 (0.74) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL11993894 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL6940855 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL9573557 | 0.82 | MAPT (0.65) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL9573457 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 | |
| SCHEMBL9091250 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EMAPTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2000014073-A1 | BENZODIAZEPINONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREFOR, USE AS MEDICINES AND COMPOSITIONS | HOECHST MARION ROUSSEL (FR) | 2000-03-16 | — | — | WO | disclosed |