Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 14/20 | 0.71 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | BCL2 | P10415 | 2/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6936324 | 0.94 | ADA (0.71) | ADAMCL1 | |
| SCHEMBL6938456 | 0.92 | ADA (0.70) | ADAMCL1 | |
| SCHEMBL6938571 | 0.89 | ADA (0.71) | ADAMCL1BCL2 | |
| SCHEMBL6936415 | 0.87 | ADA (0.60) | ADAMCL1BCL2 | |
| SCHEMBL6936327 | 0.86 | ADA (0.51) | ADA | |
| SCHEMBL6941256 | 0.86 | ADA (0.80) | ADA | |
| SCHEMBL6935293 | 0.86 | ADA (0.77) | ADAMCL1BCL2PLA2G4A | |
| SCHEMBL6933487 | 0.84 | ADA (0.49) | ADA | |
| SCHEMBL6942815 | 0.84 | ADA (0.71) | ADAMCL1 | |
| SCHEMBL6935289 | 0.83 | ADA (1.00) | ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| EP-1161429-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055155-A2 | HETEROCYCLIC COMPOUNDS AS ADENOSINE DEAMINASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-21 | — | — | WO | disclosed |