Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372232 | 0.71 | CHRM5 (0.41) | CHRM5CHRM4CHRM1CYP2C9CHRM3 | |
| SCHEMBL23480895 | 0.70 | CYP11B1 (0.36) | CYP11B1CYP11B2CHRM5OPRM1CHRM4 | |
| SCHEMBL29063413 | 0.70 | CYP11B1 (0.36) | CYP11B1CYP11B2CHRM5OPRM1CHRM4 | |
| SCHEMBL13733705 | 0.69 | MAPK1 (0.42) | CHRM5CYP3A4MAPK1 | |
| SCHEMBL10190927 | 0.69 | CHRM5 (0.39) | CHRM5CHRM4CHRM1CYP2C9CHRM3 | |
| SCHEMBL2892358 | 0.68 | CHRM5 (0.43) | CHRM5CHRM4CHRM1CYP2C9CHRM3 | |
| SCHEMBL20671646 | 0.68 | RECQL (0.42) | CHRM5CHRM4CHRM1CYP2C9CHRM3 | |
| SCHEMBL6642477 | 0.68 | PTPRB (0.51) | CYP2A6MEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL874048 | 0.66 | CHRM5 (0.41) | CHRM5CHRM4CHRM1CYP2C9CHRM3 | |
| Trifluoroacetic Acid SCHEMBL1311021 | 0.66 | CYP11B1 (0.53) | CYP11B1CYP11B2PIK3CAPIK3CGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928788-B1 | Imidazolidin-4-one derivatives useful as anticancer agents | PFIZER PROD INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| US-6174903-B1 | INHIBITORS OF THE ENZYME FARNESYL PROTEIN TRANSFERASE AND ARE THEREFORE CAN BE USED AS ANTICANCER AGENT AND ANTITUMOR AGENT | PFIZER INC. | 2001-01-16 | — | — | US | disclosed |
| US-6080769-A | Imidazolidin-4-one derivatives useful as anticancer agents | PFIZER INC. (US) | 2000-06-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |
| EP-0928788-A1 | Imidazolidin-4-one derivatives useful as anticancer agents | Pfizer Products Inc. (US) | 1999-07-14 | — | — | EP | disclosed |