Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 7/20 | 0.42 |
| ▸ | ITK | Q08881 | 4/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12256553 | 0.86 | MAPK1 (0.45) | MAPK1GPR142ITKINSRCCNE1 | |
| SCHEMBL20671646 | 0.84 | RECQL (0.42) | MAPK1GPR142ITKINSRCCNE1 | |
| SCHEMBL25217416 | 0.83 | NAMPT (0.47) | MAPK1CYP3A4SLC40A1CHRM5 | |
| SCHEMBL22213802 | 0.83 | GPR142 (0.40) | MAPK1GPR142ITKCYP3A4SLC40A1 | |
| SCHEMBL16133689 | 0.81 | MAPT (0.43) | MAPK1GPR142ITKINSRCCNE1 | |
| SCHEMBL12017902 | 0.81 | ERCC1 (0.40) | MAPK1GPR142ITKINSRCCNE1 | |
| SCHEMBL31369367 | 0.79 | AGTR1 (0.38) | MAPK1ITKINSRCCNE1CDK2 | |
| SCHEMBL4558045 | 0.78 | GPR142 (0.44) | MAPK1GPR142ITKCYP3A4SLC40A1 | |
| SCHEMBL18270992 | 0.77 | ACACB (0.43) | — | |
| SCHEMBL874048 | 0.76 | CHRM5 (0.41) | MAPK1CYP3A4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699557-B1 | 3-(OXAZOL-2-YL-ETHOXY)- AND 3-(THIAZOL-2-YL-ETHOXY)-BENZAMIDE DERIVATIVES AS ANTI-BACTERIAL AGENTS | BIOTA SCIENT MANAGEMENT (AU) | 2017-08-16 | — | — | EP | claimed |
| US-9511073-B2 | Aromatic amides and uses thereof | TAXIS PHARMACEUTICALS, INC. (US) | 2016-12-06 | — | — | US | claimed |
| EP-2699557-A1 | AROMATIC AMIDES AND USES THEREOF | Biota Scientific Management Pty Ltd (AU) | 2014-02-26 | — | — | EP | claimed |
| WO-2012142671-A1 | AROMATIC AMIDES AND USES THEREOF | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-10-26 | — | — | WO | claimed |
| WO-2022053000-A1 | CARBOCYCLIC AMIDE DERIVATIVE AND APPLICATION THEREOF IN MEDICINE | 四川海思科制药有限公司 | 2022-03-17 | — | — | WO | disclosed |
| EP-2699557-B1 | 3-(OXAZOL-2-YL-ETHOXY)- AND 3-(THIAZOL-2-YL-ETHOXY)-BENZAMIDE DERIVATIVES AS ANTI-BACTERIAL AGENTS | BIOTA SCIENT MANAGEMENT (AU) | 2017-08-16 | — | — | EP | disclosed |