Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263628 | 1.00 | KDR (0.53) | KDRPIM1AGTR1LRRK2IDO1 | |
| SCHEMBL19678415 | 0.87 | LRRK2 (0.58) | KDRAGTR1LRRK2IDO1MEN1 | |
| SCHEMBL31013507 | 0.87 | LRRK2 (0.58) | KDRAGTR1LRRK2IDO1MEN1 | |
| SCHEMBL3993251 | 0.87 | LRRK2 (0.58) | KDRAGTR1LRRK2IDO1MEN1 | |
| SCHEMBL31013508 | 0.87 | LRRK2 (0.58) | KDRAGTR1LRRK2IDO1MEN1 | |
| SCHEMBL9661928 | 0.87 | LRRK2 (0.58) | KDRAGTR1LRRK2IDO1MEN1 | |
| SCHEMBL4408992 | 0.86 | MEN1 (0.67) | KDRPIM1AGTR1LRRK2IDO1 | |
| SCHEMBL4408999 | 0.86 | MEN1 (0.67) | KDRPIM1AGTR1LRRK2IDO1 | |
| SCHEMBL4895008 | 0.85 | KMT2A (0.52) | KDRPIM1AGTR1LRRK2MEN1 | |
| SCHEMBL4895014 | 0.85 | KMT2A (0.52) | KDRPIM1AGTR1LRRK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030229453-A1 | Crystals and structures of PAK4KD kinase PAK4KD | SGX PHARMACEUTICALS, INC. | 2003-12-11 | — | — | US | disclosed |
| WO-2003087816-A1 | CRYSTALS AND STRUCTURES OF PAK4KD KINASE PAK4KD | STRUCTURAL GENOMIX, INC. (US) | 2003-10-23 | — | — | WO | disclosed |