SCHEMBL6942354

SCHEMBL6942354

O=CC=CC=P(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
TRPA1 O75762 1/20 0.43
LMNA P02545 1/20 0.43
ALOX5 P09917 1/20 0.43
MAPK1 P28482 1/20 0.43
HSP90AA1 P07900 1/20 0.37
CA2 P00918 1/20 0.36
CA4 P22748 1/20 0.36
CA5A P35218 1/20 0.36
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
CDK4 P11802 2/20 0.33
CCND1 P24385 2/20 0.33
CYP2A6 P11509 1/20 0.33
CFTR P13569 1/20 0.32
GAA P10253 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAPT P10636 1/20 0.31
ALPG P10696 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6942352 1.00 ALDH1A1 (0.43) ALDH1A1TRPA1LMNAALOX5MAPK1
SCHEMBL7196779 0.83 HSP90AA1 (0.41) ALDH1A1TRPA1LMNAALOX5MAPK1
SCHEMBL181926 0.83 HSP90AA1 (0.41) ALDH1A1TRPA1LMNAALOX5MAPK1
SCHEMBL19305261 0.79 TSHR (0.40) ALDH1A1HSP90AA1CA2CA4CA5A
SCHEMBL19305264 0.79 TSHR (0.40) ALDH1A1HSP90AA1CA2CA4CA5A
SCHEMBL17307997 0.74 HSP90AA1 (0.38) ALDH1A1HSP90AA1CA2CA4CA5A
SCHEMBL23805159 0.74 HCAR2 (0.43) ALDH1A1LMNAHSP90AA1CA2CA4
SCHEMBL13422202 0.71 TDP1 (0.47) ALDH1A1LMNAHSP90AA1CA2CA4
SCHEMBL12257188 0.70 HSP90AA1 (0.32) HSP90AA1
SCHEMBL7153777 0.69 TSHR (0.43) ALDH1A1HSP90AA1CA2CA4CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1083175-B1 Triazole derivatives having antifungal activity SANKYO CO (JP) 2003-07-02 EP disclosed
US-6392082-B1 CHEMICAL INTERMEDIATE SANKYO COMPANY, LIMITED (JP) 2002-05-21 US disclosed
US-6391903-B1 THERAPY FOR FUNGI INFECTIONS SANKYO COMPANY, LIMITED (JP) 2002-05-21 US disclosed
US-6337403-B1 CRYSTALLINE FORM OF A PHARMACEUTICAL COMPOSITION CONTAINING SAID DERIVATIVES WITH TREATING AND PREVENTING FUNGAL INFECTIONS USING BUTADIENE FLUORO BENZONITRILE GROUPS SANKYO COMPANY, LIMITED (JP) 2002-01-08 US disclosed
EP-1083175-A2 Triazole derivatives having antifungal activity Sankyo Company Limited (JP) 2001-03-14 EP disclosed
EP-0170048-B1 ALIPHATIC THIOETHERS CIBA-GEIGY AG (CH) 1991-04-17 EP disclosed
EP-0228045-B1 AROMATIC THIOETHERS CIBA-GEIGY AG (CH) 1991-04-03 EP disclosed
EP-0201823-B1 NOVEL INTERMEDIATES FOR THE PRODUCTION OF PHARMACEUTICALS LILLY INDUSTRIES LIMITED (GB) 1990-12-05 EP disclosed
US-4963578-A LEUKOTRIN ANTAGONISTS; ANTIALLERGENS LILLY INDUSTRIES LIMITED (GB) 1990-10-16 US disclosed
US-RE33300-E LEUKOTRIENE ANTAGONISTS; ANTIALLERGENS ELI LILLY AND COMPANY (US) 1990-08-14 US disclosed
EP-0134111-B1 ARALIPHATIC SULPHIDES,SULPHONES AND SULPHOXIDES AND THEIR PHARMACEUTICAL USE Lilly Industries Limited (GB) 1988-12-07 EP disclosed
EP-0228045-A2 Aromatic thioethers CIBA-GEIGY AG (CH) 1987-07-08 EP disclosed
US-4665189-A LEUKOTRIENE ANTAGONISTS LILLY INDUSTRIES LIMITED (GB) 1987-05-12 US disclosed
US-4649215-A ANTIALLERGENS CIBA-GEIGY CORPORATION (US) 1987-03-10 US disclosed
EP-0170048-A2 Aliphatic thioethers CIBA-GEIGY AG (CH) 1986-02-05 EP disclosed