SCHEMBL6942560

SCHEMBL6942560

N=C(N)c1ccc(O)c(CC(=O)Nc2ccc(-n3cnc4c3CCCC4)c(C(F)(F)F)c2)c1

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
F10 P00742 2/20 0.37
PRSS1 P07477 1/20 0.37
CSF1R P07333 4/20 0.37
ANO1 Q5XXA6 6/20 0.36
F2 P00734 2/20 0.35
F7 P08709 1/20 0.35
KDR P35968 1/20 0.35
KCNJ5 P48544 1/20 0.35
KCNJ3 P48549 1/20 0.35
MAPT P10636 2/20 0.34
TRPV1 Q8NER1 1/20 0.34
HTT P42858 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7562752 0.99 F10 (0.37) F10PRSS1CSF1RANO1F2
SCHEMBL6941666 0.88 F10 (0.39) F10PRSS1ANO1F2MAPT
Hydrochloric Acid SCHEMBL7561132 0.87 F10 (0.38) F10PRSS1ANO1F2MAPT
Hydrochloric Acid SCHEMBL7566967 0.85 F10 (0.36) F10PRSS1F7MAPTMEN1
Hydrochloric Acid SCHEMBL7562132 0.83 F10 (0.36) F10PRSS1F7
SCHEMBL6940338 0.83 F10 (0.39) F10PRSS1ANO1F2F7
Hydrochloric Acid SCHEMBL7570036 0.82 F10 (0.38) F10PRSS1ANO1F2F7
SCHEMBL2990398 0.76 F7 (0.35) F2F7
Hydrochloric Acid SCHEMBL6937642 0.76 F7 (0.35) F2F7
SCHEMBL7116247 0.75 F10 (0.52) F10PRSS1CSF1RANO1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1370540-A1 ANTI-THROMBOTIC CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND USE OF THE SAME AS MEDICAMENTS Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-12-17 EP claimed
US-20020183519-A1 Antithrombotic carboxylic acid amides BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-12-05 US claimed
WO-2002072558-A1 ANTI-THROMBOTIC CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND USE OF THE SAME AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-09-19 WO claimed
EP-1370540-A1 ANTI-THROMBOTIC CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND USE OF THE SAME AS MEDICAMENTS Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2003-12-17 EP disclosed
US-20020183519-A1 Antithrombotic carboxylic acid amides BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-12-05 US disclosed
WO-2002072558-A1 ANTI-THROMBOTIC CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND USE OF THE SAME AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020183519-A1 Antithrombotic carboxylic acid amides SERPINC1, TFPI, F2 F10 33/4885PRSS1 1106/4885CSF1R 1625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.