Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA | P00813 | 17/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942762 | 0.89 | ADA (0.73) | ADA | |
| SCHEMBL6941950 | 0.87 | ADA (0.53) | ADAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6939251 | 0.86 | ADA (0.76) | ADA | |
| SCHEMBL6942599 | 0.86 | ADA (0.63) | ADA | |
| SCHEMBL6942223 | 0.84 | ADA (0.80) | ADA | |
| SCHEMBL7848226 | 0.83 | ADA (0.52) | ADANPC1RAB9APOLB | |
| SCHEMBL6939037 | 0.83 | ADA (0.80) | ADA | |
| SCHEMBL6941946 | 0.83 | ADA (0.60) | ADA | |
| SCHEMBL6936406 | 0.82 | ADA (0.78) | ADA | |
| SCHEMBL6941827 | 0.82 | ADA (0.80) | ADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596738-B1 | Inhibiting activity to adenosine deaminase (hereinafter described as ADA) An adenosine deaminase inhibiting agent comprising a compound of the formula (I): | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |