Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 16/20 | 0.76 |
| ▸ | METAP1 | P53582 | 10/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487005 | 1.00 | METAP2 (0.76) | METAP2METAP1NPC1RAB9ATAS1R3 | |
| SCHEMBL6477810 | 0.89 | METAP2 (0.67) | METAP2METAP1 | |
| SCHEMBL6486408 | 0.88 | METAP2 (0.70) | METAP2METAP1 | |
| SCHEMBL6478050 | 0.88 | METAP2 (0.74) | METAP2METAP1NPC1RAB9ATAS1R3 | |
| SCHEMBL6477162 | 0.87 | METAP2 (0.82) | METAP2METAP1 | |
| SCHEMBL6477809 | 0.87 | METAP2 (0.75) | METAP2METAP1 | |
| SCHEMBL6476117 | 0.87 | METAP2 (0.82) | METAP2METAP1 | |
| SCHEMBL6477373 | 0.86 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL6484860 | 0.86 | METAP2 (1.00) | METAP2METAP1 | |
| SCHEMBL6490543 | 0.86 | METAP2 (0.80) | METAP2METAP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |