SCHEMBL6943183

SCHEMBL6943183

CCCn1c(=O)cc(C)c2cnc(Nc3ccc(F)c(C)c3)nc21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 17/20 0.52
CCND1 P24385 17/20 0.52
CCND2 P30279 17/20 0.52
CCND3 P30281 17/20 0.52
FGFR1 P11362 4/20 0.49
EGFR P00533 1/20 0.49
PDGFRB P09619 1/20 0.49
SRC P12931 1/20 0.49
PDGFRA P16234 1/20 0.49
STAT5A P42229 1/20 0.49
ACVR1 Q04771 1/20 0.49
PKMYT1 Q99640 1/20 0.49
CCNB2 O95067 3/20 0.49
CDK1 P06493 3/20 0.49
CCNB1 P14635 3/20 0.49
CCNB3 Q8WWL7 3/20 0.49
FGFR2 P21802 3/20 0.49
FGFR4 P22455 3/20 0.49
FGFR3 P22607 3/20 0.49
CCNE2 O96020 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6806234 0.86 CDK4 (0.67) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6943178 0.81 CDK4 (0.63) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6807977 0.80 CDK4 (0.69) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL7511299 0.80 CDK4 (0.64) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6944082 0.79 CDK4 (0.50) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6812155 0.78 CDK4 (0.67) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6940718 0.78 CDK4 (0.70) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6939784 0.78 CDK4 (0.56) CDK4CCND1CCND2CCND3CCNB2
SCHEMBL6945124 0.78 CDK4 (0.70) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL6808782 0.78 CDK4 (0.73) CDK4CCND1CCND2CCND3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP claimed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO claimed
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP disclosed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO disclosed