Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.56 |
| ▸ | CCND1 | P24385 | 5/20 | 0.56 |
| ▸ | CCND2 | P30279 | 5/20 | 0.56 |
| ▸ | CCND3 | P30281 | 5/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940718 | 0.90 | CDK4 (0.70) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL6939778 | 0.84 | CDK4 (0.64) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6939302 | 0.83 | CCND3 (0.58) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6938891 | 0.82 | CDK4 (0.81) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6939295 | 0.81 | CDK4 (0.80) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6943183 | 0.78 | CDK4 (0.52) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6940089 | 0.76 | CDK4 (0.72) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6940707 | 0.76 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7079053 | 0.76 | CDK4 (0.68) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6942006 | 0.76 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |