Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.56 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | ANPEP | P15144 | 2/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.30 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.30 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942268 | 0.98 | ADAM17 (0.55) | ADAM17OXTRCTSCTGFBR1ALDH1A1 | |
| SCHEMBL6943403 | 0.98 | ADAM17 (0.55) | ADAM17OXTRCTSCTGFBR1ALDH1A1 | |
| SCHEMBL6947109 | 0.93 | ADAM17 (0.57) | ADAM17CTSCTGFBR1ALDH1A1GAA | |
| SCHEMBL6939914 | 0.93 | ADAM17 (0.57) | ADAM17CTSCTGFBR1ALDH1A1GAA | |
| SCHEMBL6939910 | 0.93 | ADAM17 (0.57) | ADAM17CTSCTGFBR1ALDH1A1GAA | |
| SCHEMBL6943561 | 0.93 | ADAM17 (0.67) | ADAM17CTSCTGFBR1ALDH1A1GAA | |
| SCHEMBL6946929 | 0.92 | ADAM17 (0.55) | ADAM17CTSCTGFBR1P2RX3APP | |
| SCHEMBL6946967 | 0.91 | ADAM17 (0.55) | ADAM17TGFBR1ALDH1A1GAAP2RX3 | |
| SCHEMBL6945556 | 0.91 | ADAM17 (0.58) | ADAM17TGFBR1P2RX3APPMMP2 | |
| SCHEMBL6942461 | 0.91 | ADAM17 (0.56) | ADAM17TGFBR1P2RX3APPMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |