Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450743 | 0.92 | MAOB (0.77) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL2570286 | 0.87 | MEN1 (0.84) | MAOBMEN1KMT2ANR4A2SMN1; SMN2 | |
| SCHEMBL9967900 | 0.86 | MAOB (0.68) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL13703968 | 0.85 | MAOB (0.67) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL90412 | 0.85 | LMNA (0.69) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL9371922 | 0.85 | MAOB (0.67) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL7110511 | 0.85 | MAOB (0.67) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL29475634 | 0.85 | LMNA (0.69) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL14255438 | 0.84 | SRD5A2 (0.65) | MAOBMEN1KMT2ANR4A2ALDH1A1 | |
| SCHEMBL14456109 | 0.84 | MAOB (0.65) | MAOBMEN1KMT2ANR4A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449599-B2 | Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | MERCK + CO INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070254958-A1 | Phenyl Carboxamide Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | MERCK SHARP & DOHME CORP. | 2007-11-01 | — | — | US | disclosed |
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| EP-0043807-B1 | 1-(DIHYDROXYPHENYL)-2-AMINO-ETHANOL DERIVATIVES; PREPARATION, COMPOSITIONS AND INTERMEDIATES | Aktiebolaget Draco (SE) | 1984-05-30 | — | — | EP | disclosed |
| US-4451663-A | TERBUTALINE DERIVATIVES OF LONG DURATION AN REDUCED SIDE EFFECTS | AKTIEBOLAGET DRACO (SE) | 1984-05-29 | — | — | US | disclosed |
| US-4419364-A | Bronchospasmolytic carbamate derivatives | AKTIEBOLAGET DRACO (SE) | 1983-12-06 | — | — | US | disclosed |
| EP-0043807-A2 | 1-(Dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates | Aktiebolaget Draco (SE) | 1982-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254958-A1 | Phenyl Carboxamide Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | BACE1, BACE2, APP | MAOB 319/4885MEN1 3310/4885KMT2A 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.