Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373850 | 0.92 | KMT2A (0.75) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6943767 | 0.86 | KMT2A (0.58) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6938002 | 0.85 | MEN1 (0.66) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL6939392 | 0.85 | MEN1 (0.79) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL13265723 | 0.82 | CYP11B1 (0.69) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL13265690 | 0.80 | CYP11B2 (0.63) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL3180203 | 0.79 | KMT2A (1.00) | KMT2AMEN1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL6939719 | 0.79 | KDR (0.61) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL6943802 | 0.79 | MEN1 (0.68) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL6936821 | 0.79 | MEN1 (0.68) | KMT2AMEN1ALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042278-B1 | 1,3-DISUBSTITUTED UREAS AS ACAT INHIBITORS, AND METHOD OF PREPARING THEREOF | SLOVAKOFARMA AS (SK) | 2003-03-05 | — | — | EP | disclosed |
| US-6444691-B1 | ANTICHOLESTEROL AGENTS | SOLVAKOFARMA, A.S. (SK) | 2002-09-03 | — | — | US | disclosed |