Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 8/20 | 0.63 |
| ▸ | FEN1 | P39748 | 8/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.63 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29489791 | 0.87 | PTPN1 (0.71) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL1974978 | 0.87 | PTPN1 (0.71) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL3373461 | 0.85 | PTPN1 (0.65) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL1003111 | 0.85 | KDM4E (0.65) | ERCC5FEN1PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL29483367 | 0.85 | KDM4E (0.65) | ERCC5FEN1PTPN1SMN1; SMN2KDM4E | |
| SCHEMBL8592709 | 0.81 | PTPN1 (0.56) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL6547612 | 0.81 | PTPN1 (0.59) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL7449918 | 0.80 | PTPN1 (0.62) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL2774094 | 0.80 | SMN1; SMN2 (0.72) | PTPN1SMN1; SMN2KDM4EHPGDCES2 | |
| SCHEMBL2038455 | 0.80 | MEN1 (0.63) | ERCC5FEN1PTPN1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |