Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.40 |
| ▸ | CCND1 | P24385 | 6/20 | 0.40 |
| ▸ | CCND3 | P30281 | 6/20 | 0.40 |
| ▸ | CCND2 | P30279 | 3/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL4832629 | 0.87 | CDK4 (0.40) | CDK4CCND1CCND3CCND2CDK6 | |
| Methane SCHEMBL4832996 | 0.87 | CDK4 (0.40) | CDK4CCND1CCND3CCND2CDK6 | |
| Methane SCHEMBL28462345 | 0.81 | CDK4 (0.31) | CDK4CCND1CCND3CDK6 | |
| Methane SCHEMBL28899488 | 0.81 | PDE10A (0.31) | CDK4CCND1CCND3CDK6 | |
| Methane SCHEMBL4833545 | 0.81 | CDK4 (0.40) | CDK4CCND1CCND3CCND2 | |
| Methane SCHEMBL28473469 | 0.80 | CDK4 (0.32) | CDK4CCND1CCND3CDK6 | |
| Methane SCHEMBL4833066 | 0.80 | CDK4 (0.46) | CDK4CCND1CCND3CCND2CDK6 | |
| Methane SCHEMBL28467040 | 0.79 | PLAT (0.35) | — | |
| Methane SCHEMBL4826692 | 0.78 | CDK2 (0.37) | CDK4CCND1CCND3CCND2CDK6 | |
| Methane SCHEMBL4828675 | 0.78 | CDK2 (0.44) | CDK4CCND1CCND3CCND2CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |