Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | PKLR | P30613 | 4/20 | 0.32 |
| ▸ | PKM | P14618 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167260 | 0.88 | CREBBP (0.32) | ALDH1A1LMNA | |
| SCHEMBL6943398 | 0.84 | BACE1 (0.47) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL7017893 | 0.84 | BACE1 (0.38) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL7017885 | 0.84 | BACE1 (0.38) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL1970088 | 0.77 | BACE1 (0.48) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL1965193 | 0.77 | BACE1 (0.48) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL6276745 | 0.72 | ATM (0.38) | ALDH1A1KDM4ENPSR1 | |
| SCHEMBL5167594 | 0.71 | ATM (0.37) | MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7015907 | 0.71 | CREBBP (0.43) | BACE1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL5168422 | 0.69 | GAA (0.41) | BACE1GAAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | claimed |
| JP-2003517466-A | — | — | 2003-05-27 | — | — | JP | claimed |
| EP-1218380-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027110-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1218380-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027110-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |