Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | TP53 | P04637 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | PKLR | P30613 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 9/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169227 | 0.85 | CREBBP (0.56) | CREBBPMAPTTP53POLBGAA | |
| SCHEMBL1000016 | 0.81 | ADORA1 (0.45) | CREBBPMAPTTP53POLBGAA | |
| SCHEMBL1970088 | 0.78 | BACE1 (0.48) | BACE1MAPTTP53GAAALDH1A1 | |
| SCHEMBL1965193 | 0.78 | BACE1 (0.48) | BACE1MAPTTP53GAAALDH1A1 | |
| SCHEMBL7015910 | 0.76 | TP53 (0.60) | CREBBPMAPTTP53POLBPKLR | |
| SCHEMBL5167055 | 0.74 | ALOX5 (0.46) | BACE1MAPTTP53POLBGAA | |
| SCHEMBL6944016 | 0.71 | BACE1 (0.40) | BACE1MAPTTP53PKLRPKM | |
| SCHEMBL7017885 | 0.71 | BACE1 (0.38) | BACE1MAPTTP53PKLRPKM | |
| SCHEMBL7017893 | 0.71 | BACE1 (0.38) | BACE1MAPTTP53PKLRPKM | |
| SCHEMBL6651475 | 0.71 | CREBBP (0.40) | CREBBPMAPTTP53GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218380-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | GRUENENTHAL GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1218380-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027110-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |