SCHEMBL6944019

SCHEMBL6944019

Cc1cc(-n2ccnc2)c2cccc(OCc3c(Cl)ccc(S(=O)(=O)N4CCC[C@H]4C(=O)NC4CC4)c3Cl)c2n1

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 19/20 0.88
BDKRB2 P30411 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6941528 0.98 RORC (0.87) RORCBDKRB2
SCHEMBL6944574 0.94 RORC (1.00) RORCBDKRB2
SCHEMBL6943374 0.94 RORC (1.00) RORCBDKRB2
SCHEMBL6941518 0.92 RORC (0.96) RORCBDKRB2
SCHEMBL6944528 0.92 RORC (0.86) RORCBDKRB2
SCHEMBL6945236 0.92 RORC (0.86) RORCBDKRB2
SCHEMBL6944446 0.91 RORC (0.86) RORCBDKRB2
SCHEMBL6941622 0.91 RORC (0.86) RORCBDKRB2
SCHEMBL6939254 0.91 RORC (0.86) RORCBDKRB2
SCHEMBL6946215 0.91 RORC (0.85) RORCBDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1155013-B1 HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS FOURNIER IND & SANTE (FR) 2003-07-23 EP disclosed
US-6479515-B1 FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS FOURNIER INDUSTRIE ET SANTE (FR) 2002-11-12 US disclosed