SCHEMBL6944057

SCHEMBL6944057

CNC(=O)CC(C)(C)N

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30063344 0.79
SCHEMBL681118 0.78
SCHEMBL16092680 0.76 HMGCR (0.50)
SCHEMBL4282052 0.76
SCHEMBL12464050 0.75 MCL1 (0.41)
SCHEMBL13247988 0.75 LMNA (0.44)
SCHEMBL6205081 0.75 MCL1 (0.34)
SCHEMBL19010446 0.75 KDM4E (0.54)
SCHEMBL9925425 0.75 MCL1 (0.42)
SCHEMBL24920461 0.74 MCL1 (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3357918-A1 NOVEL PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2018-08-08 EP claimed
EP-2928881-B1 NOVEL PYRIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2018-03-14 EP claimed
US-9522886-B2 Pyridine derivatives HOFFMANN-LA ROCHE INC. (US) 2016-12-20 US claimed
US-20150307452-A1 NOVEL PYRIDINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2015-10-29 US claimed
EP-2928881-A1 NOVEL PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2015-10-14 EP claimed
WO-2014086705-A1 NOVEL PYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-06-12 WO claimed
CN-112480121-A Polycyclic derivative and preparation thereof 四川海思科制药有限公司 2021-03-12 CN disclosed
WO-2019013789-A1 ANTIMICROBIAL COMPOUNDS CURZA GLOBAL, LLC (US) 2019-01-17 WO disclosed
EP-3357918-A1 NOVEL PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2018-08-08 EP disclosed
EP-2928881-B1 NOVEL PYRIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2018-03-14 EP disclosed
US-9522886-B2 Pyridine derivatives HOFFMANN-LA ROCHE INC. (US) 2016-12-20 US disclosed
US-20150307452-A1 NOVEL PYRIDINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2015-10-29 US disclosed
EP-2928881-A1 NOVEL PYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2015-10-14 EP disclosed
WO-2014086705-A1 NOVEL PYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-06-12 WO disclosed
EP-0796646-B1 Method for the removal of carbon dioxide present in gases and absorbent KANSAI ELECTRIC POWER CO (JP) 2003-11-12 EP disclosed
US-6051161-A BRINGING A CARBON DIOXIDE CONTAINING GAS INTO CONTACT WITH AN AQUEOUS SOLUTION CONTAINING AT LEAST ONE AMINE COMPOUND; REDUCTION IN THERMAL ENERGY REQUIRED FOR REGENERATION OF THE AQUEOUS SOLUTION THE KANSAI ELECTRIC POWER CO., INC. (JP) 2000-04-18 US disclosed
EP-0796646-A1 Method for the removal of carbon dioxide present in gases and absorbent THE KANSAI ELECTRIC POWER CO., INC. (JP) 1997-09-24 EP disclosed
US-5468746-A A dicarboxy-4-aryldihydropyridine ZAMBON GROUP S.P.A. (IT) 1995-11-21 US disclosed
EP-0352863-A2 1,4-Dihydropyridine dicarboxylic acid derivatives ZAMBON GROUP S.p.A. (IT) 1990-01-31 EP disclosed