Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547881 | 0.91 | CYP2C19 (0.46) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL27902708 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL28887606 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL5030692 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL10621210 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL19976105 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| Bicarbonate SCHEMBL18954885 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL8352054 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL20912559 | 0.89 | CYP2C19 (0.44) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 | |
| SCHEMBL5034921 | 0.84 | ALDH1A1 (0.37) | CYP2C19HIF1ACYP2D6TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305390-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1305389-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008371-A2 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002008370-A2 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002008375-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002008376-A1 | CLEANING COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2002-01-31 | — | — | WO | disclosed |