Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.64 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 10/20 | 0.39 |
| ▸ | MMP1 | P03956 | 7/20 | 0.39 |
| ▸ | MMP3 | P08254 | 6/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 7/20 | 0.39 |
| ▸ | MMP7 | P09237 | 4/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940945 | 0.92 | ADAM17 (0.75) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6940838 | 0.90 | ADAM17 (0.63) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6945656 | 0.87 | ADAM17 (0.71) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6940122 | 0.87 | ADAM17 (0.63) | ADAM17GRIK1GRIK2MMP2MMP1 | |
| SCHEMBL6945120 | 0.84 | ADAM17 (0.73) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6943011 | 0.84 | ADAM17 (0.65) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6942295 | 0.83 | ADAM17 (0.66) | ADAM17GRIK1GRIK2MMP2MMP1 | |
| SCHEMBL6940125 | 0.82 | ADAM17 (0.67) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6945858 | 0.82 | ADAM17 (0.57) | ADAM17MMP2MMP1MMP3MMP13 | |
| SCHEMBL6940910 | 0.81 | ADAM17 (0.67) | ADAM17MMP2MMP1MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |