Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945990 | 0.83 | USP2 (0.71) | POLBUSP2KMT2AMEN1HTT | |
| SCHEMBL28871030 | 0.81 | POLB (0.59) | TSHRPOLBSMN1; SMN2USP2KMT2A | |
| SCHEMBL6951550 | 0.81 | GAA (0.69) | POLBSMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL160108 | 0.81 | ATM (0.69) | ATMTSHRPOLBSMN1; SMN2USP2 | |
| SCHEMBL4759272 | 0.80 | KMT2A (0.78) | TSHRUSP2KMT2AMEN1L3MBTL1 | |
| SCHEMBL12793305 | 0.79 | POLB (0.71) | ATMTSHRPOLBSMN1; SMN2USP2 | |
| SCHEMBL9386579 | 0.79 | KMT2A (0.84) | ATMTSHRPOLBSMN1; SMN2USP2 | |
| SCHEMBL7564728 | 0.79 | KMT2A (0.84) | ATMTSHRPOLBSMN1; SMN2USP2 | |
| SCHEMBL8200020 | 0.79 | KMT2A (0.84) | ATMTSHRPOLBSMN1; SMN2USP2 | |
| SCHEMBL1156725 | 0.77 | ATM (0.69) | ATMTSHRPOLBSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |