Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951550 | 0.84 | GAA (0.69) | MAPTALDH1A1POLBGAAMEN1 | |
| SCHEMBL6944909 | 0.83 | ATM (0.63) | USP2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4655481 | 0.82 | USP2 (0.71) | USP2KDM4EMAPTALDH1A1POLB | |
| SCHEMBL4655484 | 0.82 | USP2 (0.71) | USP2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL165282 | 0.80 | KMT2A (0.69) | USP2KDM4EMAPTALDH1A1GAA | |
| SCHEMBL28285201 | 0.80 | ALDH1A1 (0.68) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL12455096 | 0.80 | USP2 (0.68) | USP2KDM4EMAPTALDH1A1POLB | |
| SCHEMBL417862 | 0.80 | USP2 (0.68) | USP2KDM4EMAPTALDH1A1POLB | |
| SCHEMBL14283239 | 0.80 | ALDH1A1 (0.70) | USP2KDM4EMAPTALDH1A1POLB | |
| SCHEMBL5432715 | 0.80 | MAPT (1.00) | KDM4EMAPTALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743304-B1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |
| EP-0743304-A1 | 4-(Arylaminomethylene)-2,4-dihydro-pyrazol-3-ones | MERCK PATENT GmbH (DE) | 1996-11-20 | — | — | EP | disclosed |