Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 12/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.58 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | RARG | P13631 | 3/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737077 | 0.87 | RARB (0.45) | OPRL1OPRM1RARBRARGCYP26A1 | |
| SCHEMBL5737385 | 0.86 | OPRM1 (0.51) | OPRL1OPRM1CYP3A4MEN1KMT2A | |
| SCHEMBL7554831 | 0.83 | OPRM1 (0.50) | OPRL1OPRM1RARBRARGCYP26A1 | |
| SCHEMBL5735066 | 0.80 | OPRL1 (0.61) | OPRL1OPRM1 | |
| SCHEMBL5736889 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1CYP3A4 | |
| SCHEMBL1351586 | 0.78 | FFAR1 (0.44) | OPRL1OPRM1MMP2MMP9MMP12 | |
| SCHEMBL5736769 | 0.75 | SMN1; SMN2 (0.46) | CYP3A4MEN1KMT2A | |
| SCHEMBL5737278 | 0.75 | RARB (0.46) | RARBRARGCYP26A1CYP3A4RARA | |
| SCHEMBL3409019 | 0.75 | OPRL1 (1.00) | OPRL1OPRM1 | |
| SCHEMBL5737444 | 0.74 | KDM1A (0.47) | RARBRARGCYP26A1CYP3A4RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366036-A2 | COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF CYTOCHROME P450RAI | Allergan, Inc. (US) | 2003-12-03 | — | — | EP | claimed |
| WO-2002018361-A2 | COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF CYTOCHROME P450RAI | ALLERGAN, INC. (US) | 2002-03-07 | — | — | WO | claimed |
| EP-1366036-A2 | COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF CYTOCHROME P450RAI | Allergan, Inc. (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002018361-A2 | COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF CYTOCHROME P450RAI | ALLERGAN, INC. (US) | 2002-03-07 | — | — | WO | disclosed |