Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 3/20 | 0.64 |
| ▸ | SELE | P16581 | 3/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.58 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943755 | 0.92 | ICAM1 (0.64) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL6936048 | 0.87 | ICAM1 (0.70) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL9366050 | 0.85 | LMNA (0.46) | ICAM1SELEMPOCYSLTR1SMN1; SMN2 | |
| SCHEMBL6938411 | 0.81 | ICAM1 (0.70) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL6940366 | 0.79 | ICAM1 (0.74) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL6945268 | 0.79 | ICAM1 (0.81) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL8443506 | 0.79 | ICAM1 (1.00) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL9362610 | 0.78 | ICAM1 (0.73) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL6940698 | 0.78 | ICAM1 (0.66) | ICAM1SELEMPOCYSLTR1VCAM1 | |
| SCHEMBL9367556 | 0.78 | P4HTM (0.48) | ICAM1SELEMPOCYSLTR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0916666-B1 | 3-(1-Methylethoxy)benzo[b]thiophene-2-carboxamides as inhibitors of cell adhesion | WARNER LAMBERT CO (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0916666-A1 | 3-alkyloxy-,aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides as inhibitors of cell adhesion | WARNER-LAMBERT COMPANY (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0628038-A1 | 3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION | WARNER-LAMBERT COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |
| US-5356926-A | Antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993017008-A1 | 3-ALKYLOXY-, ARYLOXY-, OR ARYLALKYLOXYBENZO[b]THIOPHENE-2-CARBOXAMIDES AS INHIBITORS OF CELL ADHESION | WARNER-LAMBERT COMPANY (US) | 1993-09-02 | — | — | WO | disclosed |