Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942351 | 0.85 | HTR2A (0.36) | ADAM17HTR2AGRIK1GRIK2ELANE | |
| SCHEMBL6222456 | 0.84 | ADAM17 (0.40) | ADAM17HTR2ACTSCMMP1MMP2 | |
| SCHEMBL6222466 | 0.84 | ADAM17 (0.40) | ADAM17HTR2ACTSCMMP1MMP2 | |
| SCHEMBL6222461 | 0.84 | ADAM17 (0.40) | ADAM17HTR2ACTSCMMP1MMP2 | |
| SCHEMBL7827622 | 0.81 | ADAM17 (0.38) | ADAM17HTR2ACTSCMMP1MMP2 | |
| SCHEMBL6945094 | 0.72 | ADAM17 (0.58) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6945072 | 0.72 | ADAM17 (0.58) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6945099 | 0.72 | ADAM17 (0.58) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6687622 | 0.68 | ADAM17 (0.65) | ADAM17HTR2AMMP1MMP2MMP3 | |
| SCHEMBL6687619 | 0.68 | ADAM17 (0.65) | ADAM17HTR2AMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |