Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 10/20 | 0.38 |
| ▸ | MMP2 | P08253 | 8/20 | 0.38 |
| ▸ | MMP7 | P09237 | 5/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 10/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | FCER2 | P06734 | 3/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943938 | 0.91 | ADAM17 (0.40) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6981660 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6986412 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6981614 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6983453 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6944459 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6937767 | 0.90 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6943849 | 0.89 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| Hydrochloric Acid SCHEMBL6986445 | 0.89 | ADAM17 (0.39) | ADAM17MMP3MMP2MMP7LTA4H | |
| SCHEMBL6985076 | 0.88 | ADAM17 (0.37) | ADAM17MMP3MMP2MMP7LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0993442-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999001428-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-01-14 | — | — | WO | disclosed |