Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 10/20 | 0.48 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945215 | 1.00 | ABCB1 (0.51) | ABCB1MCL1HTRA1KLK7MMP9 | |
| SCHEMBL7279809 | 0.90 | ABCB1 (0.51) | ABCB1MCL1HTRA1KLK7MMP9 | |
| SCHEMBL7287734 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL26604823 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL708630 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL1448119 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL376159 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL3179881 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL949983 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 | |
| SCHEMBL708629 | 0.89 | ABCB1 (0.52) | ABCB1MCL1KLK7UCHL1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155013-B1 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2003-07-23 | — | — | EP | disclosed |
| US-6479515-B1 | FOR THE TREATMENT OF PAIN AND INFLAMMATION, AND ESPECIALLY IN THE TREATMENT OF ASTHMA, CEREBRAL TRAUMATIC SHOCK AND ALLERGIC RHINITIS | FOURNIER INDUSTRIE ET SANTE (FR) | 2002-11-12 | — | — | US | disclosed |
| WO-2000050418-A9 | HETEROCYCLIC BENZENESULPHONAMIDE COMPOUNDS AS BRADYKININE ANTAGONISTS | FOURNIER IND & SANTE (FR) | 2001-02-22 | — | — | WO | disclosed |