Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945370 | 1.00 | ADAM17 (0.49) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6946853 | 0.94 | ADAM17 (0.50) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6986307 | 0.93 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6945800 | 0.93 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6988787 | 0.93 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6944451 | 0.93 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6984060 | 0.92 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6987312 | 0.91 | ADAM17 (0.46) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6985812 | 0.91 | ADAM17 (0.46) | ADAM17TGFBR1MMP2MMP9ANPEP | |
| SCHEMBL6982384 | 0.91 | ADAM17 (0.47) | ADAM17TGFBR1MMP2MMP9ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |