Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.61 |
| ▸ | CCND1 | P24385 | 18/20 | 0.61 |
| ▸ | CCND3 | P30281 | 15/20 | 0.61 |
| ▸ | CCND2 | P30279 | 14/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.53 |
| ▸ | CDK2 | P24941 | 9/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938617 | 0.91 | CDK4 (0.61) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6945561 | 0.87 | CDK4 (0.65) | CDK4CCND1CCND3CCND2CCNA2 | |
| Trifluoroacetic Acid SCHEMBL6942972 | 0.82 | CDK4 (0.69) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6943264 | 0.80 | CDK4 (0.66) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6942106 | 0.80 | CDK4 (0.79) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6939792 | 0.79 | CDK4 (0.57) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6938634 | 0.78 | CDK4 (0.78) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6943792 | 0.78 | CDK4 (0.68) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6944507 | 0.77 | CDK4 (0.82) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6938615 | 0.77 | CDK4 (0.82) | CDK4CCND1CCND3CCND2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |