SCHEMBL6945609

SCHEMBL6945609

CCCC(=O)Nc1c[c]c(O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.59
ALDH1A1 P00352 5/20 0.54
HPGD P15428 4/20 0.53
MAPT P10636 3/20 0.53
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
NPC1 O15118 4/20 0.49
RAB9A P51151 4/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
HTT P42858 2/20 0.49
THRB P10828 1/20 0.49
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL973371 0.77 KMT2A (0.55) ALDH1A1HPGDMAPTCA12CA1
SCHEMBL39058 0.77 TP53 (0.75) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL4628407 0.76 TP53 (0.58) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL1418810 0.73 ALDH1A1 (0.57) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL1302981 0.73 PEPD (0.55) ALDH1A1MAPTCA1CA2NPC1
SCHEMBL28675540 0.73 TP53 (0.75) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL5542468 0.73 TP53 (0.75) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL8361539 0.73 TP53 (0.75) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL8278746 0.72 TP53 (0.72) TP53ALDH1A1HPGDMAPTCA12
SCHEMBL6008352 0.72 TP53 (0.72) TP53ALDH1A1HPGDMAPTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218739-A4 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2003-06-04 EP claimed
US-6458789-B1 ANTICOAGULENTS, ANTIHISTAMINES, ANTISEPTICS, ANTIARRHYTHMICS AND ANTIRHEUMATICS LION BIOSCIENCE AG (DE) 2002-10-01 US claimed
EP-1218739-A1 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2002-07-03 EP claimed
WO-2001023887-A1 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-04-05 WO claimed
EP-1218739-A4 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2003-06-04 EP disclosed
US-6458789-B1 ANTICOAGULENTS, ANTIHISTAMINES, ANTISEPTICS, ANTIARRHYTHMICS AND ANTIRHEUMATICS LION BIOSCIENCE AG (DE) 2002-10-01 US disclosed
EP-1218739-A1 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2002-07-03 EP disclosed
WO-2001023887-A1 2-AMINOPYRIDINE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-04-05 WO disclosed