Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 3/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693552 | 0.80 | PARP1 (0.52) | PARP1MAP2K4ALDH1A1ARLMNA | |
| SCHEMBL693550 | 0.77 | NPC1 (0.39) | PARP1MAP2K4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5775137 | 0.74 | MAP2K4 (0.50) | MAP2K4ALDH1A1ALPLHSP90AB1SMN1; SMN2 | |
| SCHEMBL6583920 | 0.74 | PARP1 (0.50) | PARP1ALDH1A1ARLMNAALPL | |
| SCHEMBL16617173 | 0.74 | PDE3B (0.33) | MAP2K4 | |
| SCHEMBL188241 | 0.74 | PDE3B (0.33) | — | |
| SCHEMBL6615346 | 0.73 | HSP90AA1 (0.41) | PARP1ARHSP90AA1HSP90AB1NTRK1 | |
| SCHEMBL694632 | 0.72 | LRRK2 (0.39) | PARP1ARLMNA | |
| SCHEMBL2595676 | 0.71 | MAP2K4 (0.30) | MAP2K4 | |
| SCHEMBL694108 | 0.71 | PTGS1 (0.55) | ALDH1A1ARLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |